CBN discovery could lead to new treatments for Alzheimer\u2019s, say researchers<\/a><\/p>\nTo test the chemical medicinal properties of the four CBN analogs, the team applied them to mouse and human nerve cell cultures.<\/span><\/p>\n\u00a0When they initiated oxytosis\/ferroptosis in three different ways, they found that each of the four analogs were able to protect the cells from dying, and had similar neuroprotective abilities compared to regular CBN.<\/span><\/p>\nThe successful analogs were then put to the test in a <\/span>Drosophila <\/span><\/i>fruit fly model of traumatic brain injury.<\/span><\/p>\nOne of the analogs, CP1, was especially effective in treating traumatic brain injury\u2014producing the highest survival rate after condition onset.<\/span><\/p>\n\u201cOur findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties,\u201d says Maher.<\/span><\/p>\n\u00a0\u201cCould we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We\u2019re excited to see how effective these compounds might be in protecting the brain from further damage.\u201d<\/span><\/p>\nIn the future, the researchers will continue to screen and characterise these CBN analogs and refine their chemical designs.\u00a0<\/span><\/p>\nThey will also begin looking more closely at age-related neurodegeneration and changes in brain cells, particularly in mitochondria, asking how we can better suit these drug-like compounds to promote cellular health and prevent neuronal dysfunction with age.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"New findings suggest promise for CBN in treating neurological disorders like traumatic brain injury, Alzheimer\u2019s disease, and Parkinson\u2019s disease.<\/p>\n","protected":false},"author":4,"featured_media":24008,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_cbd_carousel_blocks":"[]","content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[134],"tags":[798,48,311,56],"yoast_head":"\n
Neuroprotective properties of CBN could point to new treatments<\/title>\n \n \n \n \n \n \n \n \n \n \n \n \n \n\t \n\t \n\t \n \n \n \n \n \n\t \n\t \n\t \n