{"id":29789,"date":"2024-04-25T09:03:34","date_gmt":"2024-04-25T08:03:34","guid":{"rendered":"https:\/\/cannabishealthnews.co.uk\/?p=29789"},"modified":"2024-04-23T16:03:53","modified_gmt":"2024-04-23T15:03:53","slug":"neuroprotective-properties-of-cbn-could-point-to-new-treatments","status":"publish","type":"post","link":"https:\/\/cannabishealthnews.co.uk\/2024\/04\/25\/neuroprotective-properties-of-cbn-could-point-to-new-treatments\/","title":{"rendered":"Neuroprotective properties of CBN could point to new treatments"},"content":{"rendered":"

New findings help explain how the lesser-known cannabinoid, CBN, protects the brain against ageing and neurodegeneration\u2014and how it could be used to develop potential therapeutics.<\/b><\/h3>\n

One in every 10 individuals above the age of 65 develops an age-related neurological disorder like Alzheimer\u2019s<\/a> or Parkinson\u2019s, yet treatment options remain sparse for this population.\u00a0<\/span><\/p>\n

Scientists have begun exploring whether cannabinoids may offer a solution. A lesser-known cannabinoid called CBN (cannabinol) has recently piqued the interest of researchers, who have begun exploring its clinical potential.<\/span><\/p>\n

Researchers at the Salk Institute created four CBN-inspired compounds that were more neuroprotective than the standard CBN molecule\u2014one of which was highly effective in treating traumatic brain injury in a <\/span>Drosophila<\/span><\/i> fruit fly model.<\/span><\/p>\n

The findings, published in <\/span>Redox Biology<\/span><\/i><\/a>, suggest promise for CBN in treating neurological disorders like traumatic brain injury, Alzheimer\u2019s disease, and Parkinson\u2019s disease, and also highlight how further studies of CBN\u2019s effects on the brain could inspire the development of new therapies for clinical use.<\/span><\/p>\n

\u201cNot only does CBN have neuroprotective properties, but its derivatives have the potential to become novel therapeutics for various neurological disorders,\u201d says Research Professor Pamela Maher, senior author of the study.<\/span><\/p>\n

\u201cWe were able to pinpoint the active groups in CBN that are doing that neuroprotection, then improve them to create derivative compounds that have greater neuroprotective ability and drug-like efficacy.\u201d<\/span><\/p>\n

Many neurological disorders involve the death of brain cells called neurons, due to the dysfunction of their power-generating mitochondria.\u00a0<\/span><\/p>\n

CBN achieves its neuroprotective effect by preventing this mitochondrial dysfunction\u2014but how exactly CBN does this, and whether scientists can improve CBN\u2019s neuroprotective abilities, has remained unclear.<\/span><\/p>\n

The Salk team previously found that CBN was modulating multiple features of mitochondrial function to protect neurons against a form of cell death called oxytosis\/ferroptosis.\u00a0<\/span><\/p>\n

After uncovering this mechanism of CBN\u2019s neuroprotective activity, they began applying both academic and industrial drug discovery methods to further characterise and attempt to improve that activity.<\/span><\/p>\n

First, they broke CBN into small fragments and observed which of those fragments were the most effective neuroprotectors by chemically analysing the fragment\u2019s properties.\u00a0<\/span><\/p>\n

Second, they designed and constructed four novel CBN analogs\u2014chemical look-alikes\u2014in which those fragments were amplified, then moved them on to drug screening.<\/span><\/p>\n

\u201cWe were looking for CBN analogs that could get into the brain more efficiently, act more quickly, and produce a stronger neuroprotective effect than CBN itself,\u201d says Zhibin Liang, first author and postdoctoral researcher in Maher\u2019s lab.\u00a0<\/span><\/p>\n

\u201cThe four CBN analogs we landed on had improved medicinal chemical properties, which was exciting and really important to our goal of using them as therapeutics.\u201d<\/span><\/p>\n

READ MORE: <\/strong>CBN discovery could lead to new treatments for Alzheimer\u2019s, say researchers<\/a><\/p>\n

To test the chemical medicinal properties of the four CBN analogs, the team applied them to mouse and human nerve cell cultures.<\/span><\/p>\n

\u00a0When they initiated oxytosis\/ferroptosis in three different ways, they found that each of the four analogs were able to protect the cells from dying, and had similar neuroprotective abilities compared to regular CBN.<\/span><\/p>\n

The successful analogs were then put to the test in a <\/span>Drosophila <\/span><\/i>fruit fly model of traumatic brain injury.<\/span><\/p>\n

One of the analogs, CP1, was especially effective in treating traumatic brain injury\u2014producing the highest survival rate after condition onset.<\/span><\/p>\n

\u201cOur findings help demonstrate the therapeutic potential of CBN, as well as the scientific opportunity we have to replicate and refine its drug-like properties,\u201d says Maher.<\/span><\/p>\n

\u00a0\u201cCould we one day give this CBN analog to football players the day before a big game, or to car accident survivors as they arrive in the hospital? We\u2019re excited to see how effective these compounds might be in protecting the brain from further damage.\u201d<\/span><\/p>\n

In the future, the researchers will continue to screen and characterise these CBN analogs and refine their chemical designs.\u00a0<\/span><\/p>\n

They will also begin looking more closely at age-related neurodegeneration and changes in brain cells, particularly in mitochondria, asking how we can better suit these drug-like compounds to promote cellular health and prevent neuronal dysfunction with age.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

New findings suggest promise for CBN in treating neurological disorders like traumatic brain injury, Alzheimer\u2019s disease, and Parkinson\u2019s disease.<\/p>\n","protected":false},"author":4,"featured_media":24008,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_cbd_carousel_blocks":"[]","content-type":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"footnotes":""},"categories":[134],"tags":[798,48,311,56],"yoast_head":"\nNeuroprotective 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