Connect with us

Mental health

Clinical trial will assess if CBD can be used to treat PTSD

A new clinical trial could be a breakthrough moment for the treatment of PTSD

Published

on

PTSD is particularly common among those who have served in the armed forces

US biotech firm Ananda Scientific has launched clinical trials of a cannabis-based treatment for post-traumatic stress disorder (PTSD).

The company has teamed up with New York University Grossman School of Medicine to carry out the eight-week study.

The Phase II double-blind, randomised trial will involve 120 patients in a large scale placebo-controlled experiment which could be a breakthrough moment for the drug.

If successful, the trial will be an important step on the journey to winning regulatory approval Ananda’s Nantheia treatment, a drug incorporating CBD into a liquid application.

PTSD is a common mental health disorder which occurs in people following a traumatic experience and is a particular problem among people who have served in the armed forces.

A 2014 study found as many as 12.9 percent of US soldiers who served in Iraq displayed some symptoms of PTSD.

Recent months have seen warnings health workers on the front line during the Covid-19 crisis could also be experiencing PTSD.

An increasing number of health workers have displayed PTSD symptoms during the pandemic.

A study in the British Medical Journal compiled earlier this year found 39.5 percent of staff on critical care wards ‘met the threshold for probable clinical significance’ when surveyed for PTSD symptoms.

The study will also evaluate its impact on patients with neurocognitive impairments resulting from a traumatic brain injury.

Sohail R. Zaidi, Ananda’s president, said: “This is an important milestone for Ananda’s clinical development program, and we look forward to continuing to work with the NYU Grossman School of Medicine.

“We are impressed by the scientific rigour and professionalism of the NYU team in getting a cutting-edge program in place to test the efficacy of our very promising drug.

“The initiation of patient enrolment in this study reinforces our commitment to our goal of improving health and wellness empowered by cannabinoid science.

“This is also an important step in our efforts to provide patients with PTSD with potentially improved therapeutic options.”

This trial is being led by Esther Blessing, assistant professor of psychiatry and Charles R. Marmar, chair of psychiatry.

Dr Marmar leads NYU’s PTSD research programme and is a leading expert in clinical trials for innovative treatments for PTSD and related conditions.

He said: “We are excited to get this important trial underway. Our collaboration with Ananda Scientific allows us to progress in the development of evidence-based CBD products for this debilitating condition.”

Mental health

Friends and CBD founders donate profits to mental health charity

10 percent of the brand’s profits will go to the Mental Health Foundation this month

Published

on

Catherine Meardon (left) and Laura Walton co-founded Moi+Me

Two friends who co-founded a CBD brand after experiencing anxiety, are donating a percentage of the company’s profits to a mental health charity this month.

Best friends and CBD co-founders, Laura Walton and Catherine Meardon know the importance of looking after your mental health.

Both of them have experienced anxiety either personally, or through a loved one. 

This June, the pair who co-founded CBD brand Moi+Me, are donating 10 percent of their profits to the Mental Health Foundation to help raise awareness. 

The charity provides support for those experiencing mental health issues, as well as campaigning to raise awareness and reduce stigma.

The friends and former colleagues founded Moi+Me after Laura’s struggles with anxiety after losing her mum.

She says discovering CBD, along with other tools and being able to be open about her experience helped her find her “way out”.

As a friend, Catherine has found it difficult to know what to say and together they wanted to build a brand that could provide tools and support, as well as taking the confusion out of CBD.

“Both of us have been touched personally by anxiety, either through our own suffering or that of those we love,” said Laura.

“I used CBD along with other tools during her mental health journey and found them to be a great support, but I didn’t want to only create a brand or product, we want to help support as much as we can by encouraging people to take extra care of themselves and have self-love.” 

She added: “It is our mission to raise further awareness of mental health, we are fully aware it can still be hard to be open about mental health in fear of being judged so by supporting this charity who in turn helps others also suffering feels a perfect fit for our brand.”

The concept for Moi + Me came from the idea that our busy lifestyles leave us feeling pulled in different directions with little time for reflection and self-care.

The range includes CBD balm, temple roller, peppermint oil mist and massage candle to encourage customers to take time for themselves.

Catherine added: “We both understand the importance of getting your life balance right. If you don’t allow time in your life for reflection and relaxation, things can very quickly feel on top of you. 

“Our busy lifestyles can leave us feeling like you have one soul and two minds. One ‘Moi’ side of us is thriving externally while the other ‘Me’ side feels tired, worn out and has too much on.  

“We’ve designed our high-quality, pure CBD product range to help bring moments of calm into your daily routine through a combination of stimulating flavours and scents.”

 

Visit www.moiandme.com

Access mental health information and support via the Mental Health Foundation 

 

Continue Reading

Mental health

How should I take CBD for anxiety?

Increasingly people are finding relief from anxiety with CBD.

Published

on

Studies suggest that CBD can have a positive impact on anxiety and stress

Living through a pandemic has made us all, understandably, a lot more anxious and increasingly people are finding relief in CBD.

Whether we’re worried about finances and or concerned for our health, what’s being termed Covid-anxiety has hit the population in a major way, with dedicated anxiety helplines even extending their hours of operation to accommodate demand.

Now, many people are turning to CBD to help them manage their anxiety – but is it effective? And, if so, how much should we be taking?

 

Is it effective?

It would appear so, yes. 

A recent two-year review of the research so far has shown that CBD can have a significant positive impact on anxiety and stress.

The report, which examined worldwide clinical papers from 2019 and 2020, was produced by Florida-based Nutrition Formulators and published in the peer-reviewed Innovare Journal of Medical Science. 

When focused specifically on anxiety, the studies showed that CBD reduced anticipator anxiety, such as speaking in public, by affecting the part of the brain that processes emotional information.

How does it work?

According to the authors of one 2015 review, CBD works by interacting with the cannabinoid type 1 receptor, the serotonin 5-HT1A receptor, and other receptors in the brain that regulate fear and anxiety-induced behaviours.

In a more recent 2020 study, researchers evaluated CBD’s effects on 397 adults with a variety of ailments.

Those who received CBD treatment for anxiety or depression reportedly experienced improvements in their ability to perform daily functions and reduce pain and anxiety or depression symptoms.

How should I take it – and much should I take?

There are a variety of CBD products on the market, so which you choose will depend largely on when and why you’re feeling anxious.

Methods include the oral route, through tinctures, oils and gummies, or more topical remedies, such as balms and creams.

For anxiety, you will probably be more suited to an oral administration method, as this will enter the bloodstream, but here too there is a world of difference between products.

The effects of orally administered CBD, such as oils, edibles, or capsules, begin working within 30 minutes to 2 hours, as they have to work their way through the digestive system. 

Products such as gummies are pleasant-tasting and discreet, meaning you can use them to relieve anxiety throughout the day. Alternatively, you could take a drop of oil in the morning with some food.

Smoking or vaping CBD oil  on the other hand, results in more immediate effects, which may help people during especially stressful events, such as giving a speech.

In terms of dosage, as with using CBD for any issue or ailment, the key is to start low and go slow.

There is a misconception that you will only get the desired effect using a higher dose, but this is far from the truth; micro-dosing can be just as effective. 

Studies have shown that between 300mg and 600mg a day is affective for controlling the symptoms of anxiety, but this is dependent on a number of factors, such as the type of CBD used and the consumer’s own health, weight and metabolism.

 

Continue Reading

Mental health

Health anxiety and how CBD could help

Health anxiety is a recognised condition, characterised by obsessive thoughts about becoming or being ill. 

Published

on

It is not surprising that living through a pandemic has caused a rise in anxiety, particularly when it comes to our health.

Health anxiety is a recognised condition, characterised by obsessive thoughts about becoming or being ill. 

According to the NHS, other symptoms include frequently checking body for signs of illness, always asking people for reassurance that you’re not ill, worries that medical tests may have missed something and obsessively looking at health information on the internet or in the media.

And with a near-constant media focus on coronavirus – its symptoms and its death rates – over the past 12 months, more and more people are suffering.

A Dutch study shortly after the pandemic hit confirmed that people who already had depressive, anxiety, or obsessive-compulsive disorders were experiencing a detrimental impact on their mental health from the Covid-19 pandemic.

For some people, the anxiety deteriorated to such an extent that could barely leave the house for fear of contracting the virus, with others leaving their jobs or spending hours washing everything that came into the house. 

How to manage symptoms

However, there are ways to manage health anxiety and lessen its impact on daily life.

In recent months particularly, sufferers have been advised to limit the time they spent scouring the media for the latest news, and to stick to only reading credible sources. 

Other advice included staying in touch with people (virtually, if necessary) and talking about any fears and worries, as well as eating a healthy diet and taking regular exercise.

The NHS also recommends keeping a diary of episodes of health anxiety, as well as techniques on how to challenge such intrusive thoughts. 

If self-help techniques do not work, cognitive behavioural therapy is also recommended, which focuses on challenging intrusive thoughts and beliefs, and gradually changing behaviour.

An alternative?

While some restrictions are still in place, and people are beginning to find what they are comfortable doing, many of the activities that are often used to ease stress and anxiety are out of bounds.

And with concern mounting about a rise in alcohol use over the course of the pandemic, they are increasingly looking for alternative ways to ease their anxiety.

Enter CBD, which is well-known to help ease symptoms of anxiety, no matter what is causing them.  

A recent poll found that more than a third (33 per cent) of Britons have tried CBD products, while 42 per cent have increased their usage since the outbreak of Covid-19, with anxiety the most common reason for using them.

In fact, it’s becoming such a popular remedy that a Canadian firm is currently developing a prescription drug based on the compound.

EmpowerPharm Inc is currently developing a unique prescription drug containing synthetic CBD as the active pharmaceutical ingredient to treat anxiety.

Earlier this year, Florida-based Nutrition Formulators published findings from a two-year study in the peer-reviewed Innovare Journal of Medical Science. 

Examining worldwide clinical papers from 2019 and 2020, researchers found that more than 70 percent of CBD research on anxiety and stress showed positive outcomes. 

The meta-analysis focused on CBD isolate and grouped the research into several categories, including CBD impacts on depression, sleep, panic attacks, dementia, inflammation, metabolism, behaviour, Parkinson’s disease, and psychiatric illnesses. 

When looking at anxiety, the studies show that CBD reduces anticipator anxiety, such as speaking in public by affecting the part of the brain that processes emotional information.

Dr Marcelo Ferro, lead author and biochemist with Nutrition Formulators, said: “After spending 10 months reviewing the research, I was surprised at how many people with anxiety and depression could be helped by incorporating CBD into their lives.”

While more research is needed – there are worries that CBD could be no more than a sticking paster for anxiety – the short-term benefits could be perfectly suited to easing the symptoms of Covid-induced health anxiety.

 

Continue Reading

Trending