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95% of patients with rare skin condition report improvements with cannabis topicals

Epidermolysis Bullosa causes severe blistering which can become infected after any trauma or friction.

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Skin condition: A white cream with a green cannabis leaf on top. It is surrounded by dark oil bottles and a spoon that has cream on it. This is on a dark background

A new study of a rare skin condition has revealed that different preparations of cannabinoids could have benefits for patients with painful Epidermolysis Bullosa (EB).

Epidermolysis Bullosa (EB) is the name of a group of rare inherited skin disorders that can cause the skin to become fragile.

It is thought to be caused by a gene mutation that makes the skin more fragile and any trauma or friction can cause painful blisters on the skin. There is currently no cure but treatment aims to prevent infection and reduce symptoms.

The study from the Netherlands and the United States analysed EB patients on five different continents who reported using cannabis preparations as a treatment for their rare skin condition.

The data is published in the Orphanet Journal of Rare Diseases. The patients reported using topical cannabinoid products in addition to inhaling cannabis flowers. They also consumed cannabis-infused edibles.

Patients were given a survey on their skin condition that focused on monitoring effects including perceived EB symptom changes, medication use, and side effects. 

Skin condition results

Results recorded that 95 percent said the topicals improved their overall skin condition symptoms with 94 percent stating their pain levels were decreased.

A further 91 percent said they had less itching and 81 reported wound healing was improved. Most of the participants at 79 percent said they had decreased their medication for their skin condition. The only side effect with a notable significance was dry mouth at 44 percent.

The authors noted that cannabis improved patient’s “perception of pain, pruritus, wound-healing, and well-being … and reduced concomitant medication use.”

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They wrote that: “Future prospective controlled clinical studies are warranted to elucidate the potential role of CBMs (cannabis-based medicines) in EB treatment.”

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Beauty & Skincare

Potyque’s new calming CBD cream aims to tackle winter skin woes

The British brand has launched a new CBD cream to help restore confidence in your skin.

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Potyque cbd cream
Potyque’s Calming Cream benefits from 400mg of terpenes in each 50ml jar

British brand Potyque has launched a new calming CBD cream to help restore skin confidence this winter.

British company, Potyque, has launched its Calming Cream packed with full spectrum CBD which provides a soothing response to topical irritation.

Just in time for winter skin troubles, although suitable for any season, the Calming Cream uses all the plant’s natural oils to deliver a potent anti-inflammatory and moisturising cream. 

Clinically blended with full spectrum CBD oil and essential plant oils, Potyque’s Calming Cream benefits from 400mg of terpenes in each 50ml jar.

Potyque CBD cream

Potyque’s Calming Cream has an array of ingredients which are recognised as anti-inflammatory and antioxidant, including:

      Theobroma cacao – also known as cocoa butter – which is rich in polyphenols, known to reduce inflammation.

      Limonene – a volatile oil with strong anti-oxidising properties.

      Alpha-pinene – the most widely encountered terpenoid in nature – highly repellent to insects.

      Beta-caryophyllene – a common terpene found in hemp but also in black pepper and

Cinnamon which acts as a very potent anti-inflammatory

The Calming Cream is paraben and SLS free, certified vegan, and not tested on animals.

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Potyque founder, Michelle Rust reveals new CBD cream

Potyque founder, Michelle Rust

Potyque founder, Michelle Rust, established the company after struggling with symptoms of the menopause and decided to create a premium range of CBD oils. With a previous career in the pharmaceutical industry, Michelle was concerned about the lack of transparency and clarity in the current CBD market and wanted to create a brand built on quality.

Michelle commented: “We are delighted to be able to introduce Potyque Calming Cream which complements our existing oil range. Numerous Potyque customers have fed back the need for a topical product to apply to inflamed, dry, flaky skin, many commenting how they have applied the oil directly to their skin to seek relief. 

“With this in mind we set out not only to incorporate the benefits of CBD oil, but to add other nourishing plant oils too, including the rich cocoa butter base.”

Promoting plant-based wellness, Potyque is designed for those struggling with life’s many challenges and juggling hectic lifestyles.

The company’s products and processes are fully compliant with national and international laws and standards, giving users peace of mind.

Potyque is a also member of the Cannabis Trades Association, which advocates for a regulated CBD market.

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Beauty & Skincare

“Innovation requires brave decisions” – Gen-Z beauty brand hits 1.7 million Tik Tok views

Love MeMeMe has successfully utilised Tik Tok marketing to attract a Gen-Z customer base

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Gen-Z: A group of young people hug in front of a camera while all are wearing a light pink colour.

 Rebekah Hall CEO at South West Brands explains the importance of influencer marketing as the brand hits 1.7 million views on TikTok with their hashtag, #metheloveofmyownlife.

New CBD brand Love, MeMeMe – which is aimed at Gen-Z consumers rather than millennials or baby boomers – offers a range of gender-neutral, self-care beauty items including lip balms, hair masks and body butter.

As part of a marketing campaign, Love, MeMeMe partnered with TikTok influencers to launch the products. Liana Jade, Miah Carter, Max Ragan, Chloe Rose, Bobbie, Elvira Styles and Hani Hans endorsed the brand on the platform. Each one of the influencers explained what self-love means to them and what their self-love tips are.

Gen-Z marketing

Gen-Z consumers are described as those born between 1997 and 2012. This explains the TikTok focus, it is estimated that by the end of this year, there will be more Gen-Z users on TikTok than on Instagram, with 37.3 million members of the Gen Z population using the platform.

Although Snapchat is currently one of the biggest platforms amongst this age group, it is thought that TikTok will overtake it by 2023.

It’s working for Love, MeMeMe who have gained 1.7 million views on the platform in just under a week.

Rebekah Hall explains that it’s about capturing the imagination and featuring new and exciting ingredients aimed to get younger beauty connoisseurs interested.

“Love, MeMeMe has really caught the imagination of our target Gen Z audience,” says Rebekah.

“It’s fun, beautifully packaged and affordably priced. I think the fact that the product portfolio is so well-considered, with ingredients like SPF and retinol working alongside CBD, has given the brand credibility.”

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She adds that Gen-Z has a different approach to CBD as they are more adventurous and interested in new products.

“I would describe Gen Z as CBD curious. They are adventurous and keen to try new things so seek out new products to see what they can do for them. They don’t necessarily view CBD through the same lens as an older audience who focus on it as a solution for symptom relief or through the lens of cannabis,” she says.

According to Rebekah, Tik Tok should be an important part of marketing to Gen-Z and brands need to be where their audience is.

“Tik Tok is the fastest growing social media platform and has completely changed the way our audience learn and ultimately shop. Creating a great brand is as much about where you turn up as how you turn up,” she adds.

“We are crystal clear about who our audience is for Love, MeMeMe, so we wanted to ensure the brand was appearing in the places that our target customers are spending their time. Innovation requires brave decisions and thinking differently and that is what we have aimed to do with Love, MeMeMe, to offer a point of difference to the CBD and skincare market.”

Gen-z: A group of beauty products in pink and red packaging

Gen-Z CBD use

These aren’t unusual figures for Gen-Z who are described as the first wave of truly digital native consumers. They aren’t just used to consistent connectivity but also, CBD and cannabis consumption becoming normalised.

In the US, a recent study from a Seattle-based cannabis data brand, Headset revealed that Gen-Z is the fastest-growing segment of the cannabis industry. In the past year, sales to Gen-Z surged by 127 percent with the biggest percentage among females. This is an even bigger amount when compared to sale increases among other generations. Millennial sales increased by 46 percent, Gen X increased by 29 percent and baby boomers by five percent.

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The same study also showed that Gen-Z prefers to smoke cannabis with only 10 percent spending money on other ways to consume CBD. This is down from 15 percent for other generations. They are also less brand loyal as well with only 20.6 percent preferring to stick to one brand.

There is more to come from Love, MeMeMe, adds Rebekah. “We’ve only just begun. You will have seen the start of our Me Movement which is a self-care squad led by British singer, songwriter, star Mae Muller and some of the biggest and most popular creators on Tik Tok. Our Me Movement will be appearing not only on Tik Tok but also spreading the self-love message in real life. Watch this space.”

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Study: Could CBD help with alopecia?

A new study on topical CBD finds it may be as effective as other treatments on the market but further testing is needed

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Alopecia: A number of hair products on a white background including two hairbrushes, a bottle of oil, a spray bottle and two towels

A new study on alopecia revealed that topical CBD use over time may help with regrowth. It could offer an alternative, non-invasive treatment for the condition.

Androgenetic alopecia can sometimes be referred to as female or male pattern baldness. It can cause thin or bald patches across the head. There are different forms of alopecia such as alopecia areata that can cause hair to fall out in patches, these may connect becoming noticeable. It develops when the immune system attacks the hair follicles. It may also affect eyebrows, eyelashes and face while developing over time.

Alopecia study

The researchers stated that the endocannabinoid system (ECS) may be involved in maintaining cellular homeostasis by regulating inflammatory response and regenerative progress.

The endocannabinoid system has three core components: endocannabinoids, receptors and enzymes. These receptors can be found throughout the body. Endocannabinoids bind to them to send signals that the system needs to be active and do something. The main two receptors are CB1 which is found in the central nervous system and CB2 in the peripheral nervous system. Cannabinoids are thought to bind or influence these receptors.

All of these receptors relate to hair follicle function. Researchers examined if blocking the CB1 receptor on the hair follicle with CBD could have a result in hair shaft elongation. They noted that the effects are dose-dependent and higher doses may have a different effect.

This study was conducted to determine if daily topical application of hemp oil high in CBD concentration would result in significant hair regrowth in the area of the scalp most affected by androgenetic alopecia (AGA)

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Alopecia treatment

The study took 35 participants with AGA and gave them a once-daily topical dose of CBD. This was on average 3 to 4 mg per day for six months. The researchers conducted a hair count of the greatest areas of alopecia before treatment and after six months. To facilitate this,  a clear acrylic mould with a cut out was made of each person’s head.

When it came to results, the men reported more regrowth than women and the vertex area did better than the temporal ones. vertex transition point refers to the area where the scalp goes from a horizontal to vertical while the temporal areas. There was an increased average of 95 percent in non-vellus hair after six months of daily use. All subjects reported some regrowth with no adverse effects.

The researchers felt that the CBD treatment offered comparable effects to other treatments on the market and could be used alongside them to maximise the effects. However, they stressed this combination would need further testing.

The authors wrote: “Topical CBD formulation has comparable results to finasteride and comparable results to 5% minoxidil once daily foam. Since the CBD works through novel mechanisms different from finasteride and minoxidil, it can be used in conjunction with these current drugs and would be expected to have synergistic effects.”

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