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Cannabinoids CBGA and CBDA may help prevent Covid-19 – study

The cannabinoid acids bind to the SARS-CoV-2 protein blocking a step in the process of infection.

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A new study has identified compounds in hemp that may have the ability to help prevent Covid-19.

A study by Oregon State University has revealed that the compounds cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA), may have the ability to prevent the virus that causes Covid-19 from entering human cells.

The success of the hemp compounds was discovered through a chemical screening technique invented at the university.

Researchers and scientists, led by Richard van Breedan, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a step in the process the virus takes for infection.

Targeting compounds that block the virus-receptor interaction has been helpful for patients with other viral infections such as HIV-1 and hepatitis.

The researchers and scientists identified the two cannabinoid acids through a screening technique, developed previously in van Breeman’s laboratory. The team also screened different botanicals such as red clover, hops, wild yam and three types of liquorice.

In a statement, Van Breeman, author of the study said:  “These cannabinoid acids are abundant in hemp and in many hemp extracts. They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

The two variants tested were earlier Covid variants, named Alpha and Beta.

He added: “These compounds can be taken orally and have a long history of safe use in humans. They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”

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“One of the primary concerns in the pandemic is the spread of variants, of which there are many, and B.1.1.7 and B.1.351 are among the most widespread and concerning.

“These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen. Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”

Van Breeman stated that while variants may still occur, CBDA and CBGA may make it a more challenging environment when combined with vaccines.

The researchers noted that one of the liquorice compounds also stuck to the spike protein too, but more funding is needed to explore the possibilities.

COVID: A scientist testing hemp and CBD oil

Previous Covid research

Previous research on Covid-19 and cannabinoids has focused on the effect that CBD may have in repairing the scarring the disease causes in the lungs.

Patients with long Covid experience a cytokine storm which is an extreme inflammatory response. If the body releases too many cytokines into the system, it can lead to acute respiratory distress syndrome (ARDS).

This inflammation can lead to severe pneumonia making breathing difficult. Research has shown that CBD may reduce a number of the inflammatory cytokines associated with Covid such as IL-6 or interleukin (IL)-2.

A pre-Covid study on asthma also showed that CBD could potentially reduce cytokine production making it easier for them to breathe. The same study also revealed that it had an effect on pulmonary fibrosis which is a thickening of the blood vessels and scarring leading to long term breathing complications.

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What is CBGA and CBDA?

There are a lot of different cannabinoids found in hemp. CBD is just one which has become popular in recent years although CBG is now also being added to products.

Cannabigerol is one of the cannabinoids found in cannabis. It is sometimes referred to as ‘the mother of all cannabinoids’ because it is the precursor to CBD. Other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.

There is very little CBG in plants often as low as one per cent so it makes CBG more expensive than CBD products. CBD is much more available in plants at 20 to 25 per cent. CBG tends to be made from younger plants which contain a higher percentage. THC and CBD both begin life as CBGA before maturing and THC goes on to become CBN in older plants.

It is thought to work the same as CBD in that it interacts with our endocannabinoid system via receptors that are found all over the body. In particular, it may bind to the CB1 receptors in our nervous system or CB2 receptors in our immune system.

It is thought to potentially strengthen the function of anandamide which is a neurotransmitter that affects our pleasure and motivation. It also regulates appetite, sleep and pain relief.

CBDA is the precursor to CBD. It is present in small amounts in the plant. Once CBDA is formed, it is converted to CBD through thermal decarboxylation. It is thought to be a powerful antioxidant and could help nausea and anxiety.

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New studies examine effects of THC and CBD on stroke

New data suggests both positive and negative effects of cannabis in stroke patients

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A new study has shown that pre-treatment CBD may have a neuroprotective effect in stroke patients.

The study aimed to investigate the effect of CBD on oxidative stress and cell death which occurs in ischemic stroke patients.

It revealed that the cannabinoid may reduce the destructive effects of cell damage associated with stroke.

Ischemic strokes are the most common type of stroke. They occur when a blood clot blocks a flow of oxygen or blood to the brain. This takes place in arteries that have been narrowed or blocked over time by fatty deposits (plaques). The most common symptoms of a stroke include facial drooping on one side, not being able to lift your arms and slurred speech.

If this occurs, it is vital that a person be taken to the emergency room immediately.

The National Institute of Health Care and Excellence (NICE) estimate that there are around 100,000 strokes every year in the UK. It is also thought that 1.3 million people live with the effects of a stroke.

Stroke recovery and CBD results

The Study showed that CBD reduced the amount of infarction in those samples which had been given the cannabinoid. Infarction refers to the death of tissue as a result of a lack of blood supply and is commonly due to a blood vessel being obstructed or narrowed.

There were also differences in malondialdehyde level (MDA) – a common marker of oxidative stress – between the brains of the CBD group and the vehicle group.

It also revealed that CBD may help to protect tissue by preventing further damage.

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THC and stroke risk

Another recent study examined the effect that tetrahydrocannabinol (THC) could have on strokes. It found that it may increase the risk of a certain type of stroke among cannabis consumers.

According to findings, cannabis consumers who experience a stroke known as an aneurysmal subarachnoid haemorrhage (aSAH), are twice as likely to develop further complications.

An aSAH occurs when a weakened blood vessel bursts on the surface of the brain leading to bleeding between the brain and tissue that covers it. It can result in neurological disabilities, long-term slurred speech or even death. It is estimated that aSAH affects around eight people per 100,000 of the population each year, accounting for six per cent of first strokes.

The study by the American Stroke Association suggested there is twice the risk of developing delayed cerebral ischemia for cannabis consumers. The researchers analysed data from 1,000 patients who had received treatment for bleeding over a 12 year period. In the group of participants, 36 per cent developed cerebral ischemia and 50 per cent had moderate to severe disabilities.

When comparing the results of patients who tested positive for THC with those who did not, they found cannabis consumers were 2.7 times more likely to develop cerebral ischemia. They were also 2.8 times more likely to develop long-term moderate to severe physical disabilities.

However, compared to those who tested negative for THC, the cannabis group did not have larger aneurysms, higher blood pressures or worse stroke symptoms when admitted to the hospital. They did not have any higher cardiovascular risk factors than the negative group.

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Researchers are now conducting further studies in which they hope to better understand if THC can impact aneurysm formation and rupture.

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New study shows CBD may prevent Covid-19 infection

Researchers are calling for more trials to determine if CBD could be a preventative or early treatment for the virus.

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Covid: A covid infection

Researchers are recommending clinical trials to examine if CBD could help to prevent Covid infection after more positive findings have been published.

Researchers from the University of Chicago have reported that CBD may stop the infection of Covid-19 by blocking its ability to replicate in the lungs.

A number of cannabinoids including CBD and THC were tested along with 7-Hydroxycannabidiol (7-OH-CBD) which is thought to be produced when cannabidiol is processed by the body.

The study found that CBD showed a significant negative association with SARS-CoV-2 positive tests in a national sample of patients who were taking  high doses of CBD, prescribed for epilepsy.

As a result of their findings, researchers are calling for more clinical trials to determine whether CBD could eventually be used as a preventative or early treatment for the virus.

Covid- Covid infection

Covid and CBD study

Researchers treated human lung cells with a non-toxic dose of CBD for two hours before exposing the cells to SARS-CoV-2 and monitoring them for the virus and the viral spike protein.

They found that, above a certain threshold concentration, CBD inhibited the virus’ ability to replicate.

Further investigation found that CBD had the same effect in two other types of cells and for three variants of SARS-CoV-2 in addition to the original strain.

CBD did not affect the ability of SARS-CoV-2 to enter the cell. Instead, CBD was effective at blocking replication early in the infection cycle and six hours after the virus had already infected the cell.

Like all viruses, SARS-CoV-2 affects the host cell by hijacking its gene expression machinery to produce more copies of itself and its viral proteins. This effect can be observed by tracking virus-induced changes in cellular RNAs. High concentrations of CBD almost completely eradicated the expression of viral RNAs.

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When it came to the other cannabinoids, CBD was found to be the only potentially potent agent. There was no or limited antiviral activity noted by the similar cannabinoids including THC, CBDA, CBDV, CBC or even CBG.

Marsha Rosner, PhD, professor and senior author of the study said it was a completely unexpected result, she commented: “CBD has anti-inflammatory effects, so we thought that maybe it would stop the second phase of COVID infection involving the immune system, the so-called ‘cytokine storm.’ Surprisingly, it directly inhibited viral replication in lung cells.

She added: “We just wanted to know if CBD would affect the immune system. No one in their right mind would have ever thought that it blocked viral replication, but that’s what it did.”

The researchers do caution that this is not possible with commercially available CBD. The CBD tested was high-purity and also medical grade.

However, Rosner cautioned:  “Going to your corner bakery and buying some CBD muffins or gummy bears probably won’t do anything. The commercially available CBD powder we looked at, which was off the shelf and something you could order online, was sometimes surprisingly of high purity but also of inconsistent quality. It is also hard to get into an oral solution that can be absorbed without the special, FDA-approved formulation.”

CBD and Covid studies

This is the second study to be released showing the potential for cannabinoids in Covid management and prevention.

A study by Oregon State University has revealed that the compounds cannabigerolic acid (CBGA) and cannabidiolic acid (CBDA), may have the ability to prevent the virus that causes Covid-19 from entering human cells.

READ MORE  Cannabis reduces blood pressure in older adults - study

Researchers and scientists, led by Richard van Breedan, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a step in the process the virus takes for infection.

Targeting compounds that block the virus-receptor interaction has been helpful for patients with other viral infections such as HIV-1 and hepatitis.

The researchers and scientists identified the two cannabinoid acids through a screening technique, developed previously in van Breeman’s laboratory. The team also screened different botanicals such as red clover, hops, wild yam and three types of liquorice.

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Could this natural compound – produced by the human body – be a substitute for CBD?

Studies show PEA may act in a similar way to CBD by interacting with our endocannabinoid system

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PEA: A bowl of soybeans containing PEA
PEA is found naturally in the body and also in soybean and egg yolks

A new review suggests that Palmitoylethanolamide (PEA) may be a safer, therapeutic alternative to CBD. But what is it and how could it help?

The review titled, ‘A Potential Alternative to Cannabidiol‘ examined if PEA could be a safer alternative to certain cannabinoids, in particular for those who may be concerned about THC in cannabis.

PEA is a chemical made from fat, which is found naturally in foods such as egg yolks and peanuts, as well as in the human body.

The report was commissioned by Gencor Pacific, a company which uses PEA in its products for sleep and sports recovery.

Researchers stated that the ambiguity surrounding the regulatory status and the insufficient studies on CBD’s efficacy, may present an opportunity for PEA. They cited a demand for alternative compounds that produce similar results but have a more defined regulatory status.

The authors wrote: “CBD… is reported to have beneficial medicinal properties including analgesic, neuroprotective, anxiolytic, anticonvulsant, and antipsychotic activities, while apparently lacking the toxicity of THC.

“With proven efficacy in several therapeutic areas, its safety and tolerability profile and the development of formulations that maximise its bioavailability, PEA is a promising alternative to CBD.”

They added: “The therapeutic actions of CBD and PEA overlap in their biochemical roles in humans. There is a need for further investigation of their pharmacokinetics, specifically regarding definitive bioavailability and volume of distribution, and safety and efficacy when used long-term in diseased and healthy populations. At this time PEA’s safety, tolerability, consistency and regulatory profile confer certain advantages.”

PEA: A compound found naturally in the body and also in soybean and egg yolks

PEA is found naturally in the body and also in soybean and egg yolks

What is PEA?

Palmitoylethanolamide (PEA) is a lipid mediator which may have anti-inflammatory, analgesic and neuroprotective benefits. It also appears to work with the endocannabinoid system in a similar way to CBD while providing the same benefits.

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It is structured in a similar way to the bliss molecule, anandamide, and may enhance its effects in the body. Anandamide is an endogenous cannabinoid known to act upon the CB1 receptors in our endocannabinoid system. CBD also affects the CB1 receptors although it is not fully understood how this happens.

PEA may also stop the production of inflammation in the body which makes it perfect for sports relief topicals. It acts as an anti-inflammatory and analgesic by binding to the TRPV-1 channel, CB1 and CB2 receptors.

Another difference between CBD and PEA is that we do not naturally produce cannabidiol in our bodies. However, PEA is found naturally in our cells, tissues, brain and fluids. It can also be found in foods such as egg yolk or soybean lecithin. PEA has been associated with relief for the common cold, eczema, influenza and neurodegenerative disorders

Why do I need an alternative to CBD?

While the study presents PEA as an alternative to CBD, it doesn’t have to be.

It can be something that is boosted naturally by eating more foods that contain it. CBD and PEA work in similar ways but may have slight differences in how they interact with receptors.

Where it may work as a substitution is for people who struggle with allergies to different terpenes in cannabis or dislike taking something related to the plant. If someone is worried about tetrahydrocannabinol (THC) appearing in drug tests if they take CBD then potentially, this may present an alternative.

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