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How can other cannabinoids boost the benefits of CBD oil?

As other cannabinoids such as CBG, CBGa and CBC are being added to CBD products, we ask what health benefits they could have

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Cannabinoids: A row of three bottles of oil sitting on a shelf with a cannabis plant in the background

There are hundreds of cannabinoids in existence that we are only starting to understand the benefits of. We examine the science behind CBG, CBC, CBN and CBDa.

Cibdol announced they are launching a new range called CBD oil 2.0. The upgraded formula combines multiple hemp extracts to work with their CBD. This will be the first of its kind in Europe.

It signals the rise of a new CBD oil category in wellness, CBD with added extras such as different cannabinoids, terpene profiles and adaptogens.

The CBD 2.0 oil contains different levels of extracts found in hemp that have a bigger impact on the mind and body. It also contains essential compounds such as CBG, CBC, CBN, CBDa alongside high purity CBD.

Samira Ramsahai, Cibdol CEO said: “As forerunners in the industry, we want to maximize hemp’s favourable impact on human health. Using the latest scientific studies as a guide, our enhanced formula greatly improves the levels of the smaller compounds to create a more powerful experience.

“It’s believed that these elements not only work better together, but each exerts a unique influence on receptors and systems spread all over the body. The greater the ratio of smaller compounds alongside CBD, the greater the chance to address specific health issues.”

Cannabinoids: A person using a dropper to draw oil from a bottle

What health benefits do other cannabinoids have?

CBG

Cannabigerol is predicted to be one of the biggest wellness trends for 2022. Brands have been keen to add extracts of this cannabinoid into the products. CBG is the precursor to CBD. Other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.

There is little CBG in plants at its lowest it could be just one per cent. This makes CBG more expensive than other cannabinoid products. In comparison, CBD is much more available in plants at 20 to 25 per cent. CBG tends to be made from younger plants which contain a higher percentage.

It works in a similar way to CBD in that it interacts with our endocannabinoid system through the receptors that are found all over our bodies. It may bind to the CB1 receptors in our nervous system or CB2 receptors found in our immune system.

One of the most promising and impressive studies on CBG show that it is may help with antibiotic resistance.

Some ‘superbugs’ have stopped responding to antibiotics over the years due to our over-reliance on them. A study from 2020 shows that CBG could be a powerful antibacterial compound that could lead to new drugs being developed. It was found to be potentially effective in mice fighting a resilient form of bacteria called methicillin-resistant Staphylococcus aureus (MRSA).

This antibacterial benefit could make it a game-changer for skincare aimed at helping with acne. It may help to prevent infections caused by skin breaking. This could make it beneficial for anyone with psoriasis or eczema where the skin can be broken due to scratching.

CBC

CBC stands for cannabichromene and it’s a rising cannabinoid in medical research. It comes from CBG, as all other cannabinoids do. CBC is non-intoxicating so it won’t give you a high like THC will.  It is very similar to CBD in that respect.

However, unlike CBD, it doesn’t bind very well to the receptors, CB1 and CB2. Instead, it communicates with our vanilloid receptor 1 (TRPV1) and our transient receptor potential ankyrin 1 (TRPA1). CBC may block pain and inflammation. In an animal study on CBC and THC, it was determined that while both produced effects separately, they were more powerful when they were combined.

Its anti-inflammatory properties may make it a great addition to skincare to help fight rosacea or acne. It may also be great for muscle pain, or post-workout strain if added to topicals.

Cannabinoids: A range of different bottles, tubs and containers for CBD oil. A mortar and pestle has cannabis leaves in it

CBN

Cannabinol is the reason why we may have to wait for this product to hit the UK. CBN is not currently legal in the UK and many other European countries. There are some that do allow THC and CBN such as the Netherlands where Cibdol is based.

The reason CBN is illegal is that it is formed when the THC in cannabis plants is exposed to air and they start to age. However, CBN is not stale THC, it is fast becoming recognised for having its benefits although it was once thought of as a waste product.

There are few studies on this cannabinoid but they do tend to be very recent. One study from 2020 on patients with Attention Deficit Hyperactive Disorder (ADHD) tested lower and higher doses of CBN. Of the 59 adults, those who were on higher doses recorded less medication use. Those on the lower doses recorded less anxiety.

CBDa

CBDa stands for cannabidiolic acid. It converts to CBD with time and heat. It doesn’t interact with the same receptors as CBD though, it prefers to work with the cyclooxygenase-2 (COX-2) enzyme. This enzyme is associated with inflammation. usually caused by infection or an injury.

One of the most impressive benefits of CBDa is that it may be anticonvulsive. It is thought to have 100 times the interaction with the 5-HT receptors in comparison to CBD. The 5-HT receptors are found in the central and peripheral nervous systems. CBDa may have better bioavailability than CBD so we can absorb it faster.

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