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How can other cannabinoids boost the benefits of CBD oil?

As other cannabinoids such as CBG, CBGa and CBC are being added to CBD products, we ask what health benefits they could have

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Cannabinoids: A row of three bottles of oil sitting on a shelf with a cannabis plant in the background

There are hundreds of cannabinoids in existence that we are only starting to understand the benefits of. We examine the science behind CBG, CBC, CBN and CBDa.

Cibdol announced they are launching a new range called CBD oil 2.0. The upgraded formula combines multiple hemp extracts to work with their CBD. This will be the first of its kind in Europe.

It signals the rise of a new CBD oil category in wellness, CBD with added extras such as different cannabinoids, terpene profiles and adaptogens.

The CBD 2.0 oil contains different levels of extracts found in hemp that have a bigger impact on the mind and body. It also contains essential compounds such as CBG, CBC, CBN, CBDa alongside high purity CBD.

Samira Ramsahai, Cibdol CEO said: “As forerunners in the industry, we want to maximize hemp’s favourable impact on human health. Using the latest scientific studies as a guide, our enhanced formula greatly improves the levels of the smaller compounds to create a more powerful experience.

“It’s believed that these elements not only work better together, but each exerts a unique influence on receptors and systems spread all over the body. The greater the ratio of smaller compounds alongside CBD, the greater the chance to address specific health issues.”

Cannabinoids: A person using a dropper to draw oil from a bottle

What health benefits do other cannabinoids have?

CBG

Cannabigerol is predicted to be one of the biggest wellness trends for 2022. Brands have been keen to add extracts of this cannabinoid into the products. CBG is the precursor to CBD. Other cannabinoids are derived from cannabigerolic acid (CBGA), an acidic form of CBG.

There is little CBG in plants at its lowest it could be just one per cent. This makes CBG more expensive than other cannabinoid products. In comparison, CBD is much more available in plants at 20 to 25 per cent. CBG tends to be made from younger plants which contain a higher percentage.

It works in a similar way to CBD in that it interacts with our endocannabinoid system through the receptors that are found all over our bodies. It may bind to the CB1 receptors in our nervous system or CB2 receptors found in our immune system.

One of the most promising and impressive studies on CBG show that it is may help with antibiotic resistance.

Some ‘superbugs’ have stopped responding to antibiotics over the years due to our over-reliance on them. A study from 2020 shows that CBG could be a powerful antibacterial compound that could lead to new drugs being developed. It was found to be potentially effective in mice fighting a resilient form of bacteria called methicillin-resistant Staphylococcus aureus (MRSA).

This antibacterial benefit could make it a game-changer for skincare aimed at helping with acne. It may help to prevent infections caused by skin breaking. This could make it beneficial for anyone with psoriasis or eczema where the skin can be broken due to scratching.

CBC

CBC stands for cannabichromene and it’s a rising cannabinoid in medical research. It comes from CBG, as all other cannabinoids do. CBC is non-intoxicating so it won’t give you a high like THC will.  It is very similar to CBD in that respect.

However, unlike CBD, it doesn’t bind very well to the receptors, CB1 and CB2. Instead, it communicates with our vanilloid receptor 1 (TRPV1) and our transient receptor potential ankyrin 1 (TRPA1). CBC may block pain and inflammation. In an animal study on CBC and THC, it was determined that while both produced effects separately, they were more powerful when they were combined.

Its anti-inflammatory properties may make it a great addition to skincare to help fight rosacea or acne. It may also be great for muscle pain, or post-workout strain if added to topicals.

Cannabinoids: A range of different bottles, tubs and containers for CBD oil. A mortar and pestle has cannabis leaves in it

CBN

Cannabinol is the reason why we may have to wait for this product to hit the UK. CBN is not currently legal in the UK and many other European countries. There are some that do allow THC and CBN such as the Netherlands where Cibdol is based.

The reason CBN is illegal is that it is formed when the THC in cannabis plants is exposed to air and they start to age. However, CBN is not stale THC, it is fast becoming recognised for having its benefits although it was once thought of as a waste product.

There are few studies on this cannabinoid but they do tend to be very recent. One study from 2020 on patients with Attention Deficit Hyperactive Disorder (ADHD) tested lower and higher doses of CBN. Of the 59 adults, those who were on higher doses recorded less medication use. Those on the lower doses recorded less anxiety.

CBDa

CBDa stands for cannabidiolic acid. It converts to CBD with time and heat. It doesn’t interact with the same receptors as CBD though, it prefers to work with the cyclooxygenase-2 (COX-2) enzyme. This enzyme is associated with inflammation. usually caused by infection or an injury.

One of the most impressive benefits of CBDa is that it may be anticonvulsive. It is thought to have 100 times the interaction with the 5-HT receptors in comparison to CBD. The 5-HT receptors are found in the central and peripheral nervous systems. CBDa may have better bioavailability than CBD so we can absorb it faster.

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Advocacy

Fair Trials and Last Prisoner Project seek to launch global cannabis justice project

Fair Trials’ Global CEO Norman L. Reimer to discuss the project at Cannabis Europa Conference in London on June 29.

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A new initiative from Fair Trials and the Last Prisoner Project aims to redress the harm caused by cannabis prohibition and to secure relief for those in prison for cannabis-related convictions.

The criminal justice reform NGO, Fair Trials hopes that the industry will support its work in countries across the globe where cannabis laws are being liberalised. Through collaboration with local partners in appropriate jurisdictions, the Fair Trials project will identify people in need of legal assistance, and recruit, train and match volunteer lawyers to take on their cases.

Fair Trials has enlisted the help of the Last Prisoner Project, a coalition of cannabis industry leaders, executives and artists dedicated to bringing restorative justice to the cannabis sector.

More and more jurisdictions are allowing adults to use and distribute medical and recreational cannabis. But after decades of prohibition, countless people remain behind bars or continue to suffer the collateral consequences of a cannabis conviction.

US research programme studies cannabinoids in ovarian cancer

“The injustice of cannabis prohibition has resulted in millions of people worldwide serving time in prison or being saddled with a cannabis conviction, which brings with it a lifetime of harmful consequences, ranging from education and employment opportunities to immigration status and parental rights,” said Fair Trials Global CEO, Norman L Reimer.

“Of course, these harmful effects of prohibition not only impact the individuals charged, but also their families and communities. And those effects have been borne disproportionately by minorities, communities of colour, and the socio-economically disadvantaged. Legalising cannabis alone does not equal justice. Together, we must address the ongoing harms of past prohibition and leave no cannabis prisoner behind.”

The project will be modelled on the US Cannabis Justice Initiative, a collaborative effort between the cannabis industry and volunteer lawyers in the United States. When Norman Reimer was the Executive Director of the National Association of Criminal Defense Lawyers (NACDL), he partnered with the Last Prisoner Project to establish the initiative.

“Key to the success of the initiative has been generous donations from legal cannabis companies and consumers nationwide,” said Last Prisoner Project Co-Founder Steve DeAngelo. “Fair Trials, with its global reach as the world’s criminal justice watchdog, is uniquely positioned to build and house the infrastructure that’s going to be needed.”

Tomorrow (29 June), Norman Reimer will address the Cannabis Europa Conference discussing the project. Mr Reimer will be part of a panel entitled ‘Leave No Cannabis Prisoner Behind,’ and will be joined on that panel by Mary Bailey, Managing Director at the Last Prisoner Project; Dr. Laura Garius, Policy Lead at Release; and Denzel Uba, an individual impacted by criminal cannabis prohibition.

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TOWIE star Amy Childs launches CBD range in honour of Jorja Foundation

The product range sees a portion of the proceeds going to the Jorja Foundation.

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Amy Childs at the launch of her new CBD range, Jorja Botanicals

TOWIE star Amy Childs launched her new CBD range this week, with a star-studded event that shone a spotlight on the story of six-year-old Jorja Emerson.

Amy Childs was joined by former Love Islanders, Amy Hart and Cara Delahoyde-Massey, alongside her  co-stars, Frankie Essex, Tom Skinner, Carina Lepore, Saffron Lempriere and Mark Ferris, for a heart-warming event celebrating the launch of her new CBD Infused beauty range, Jorja Botanicals.

The signature collection sees a portion of the proceeds going to the Jorja Foundation, which was set up in honour of six-year-old medical cannabis patient, Jorja Emerson.

The event saw The Only Way Is Essex star Frankie Essex, break down in tears as she heard Jorja’s story. Frankie, who gave birth to twins four weeks ago, wiped her eyes when Robin Emerson, Jorja’s father, showed videos of the life-threatening seizures his daughter was suffering before they discovered medical cannabis

Love Island star, Amy Hart has since taken to Instagram to spread the word about the latest political campaign that sees Childs and Emerson petitioning to make medical cannabis more widely available on the NHS

The Jorja Botanicals range was inspired by Jorja, who was diagnosed with a rare chromosome abnormality called 1q43q44 deletion, which has a side effect of life-threatening seizures. Her illness resulted in her being admitted to intensive care on two separate occasions, where Robin was told that she may not make it.

jorja botanicals

TOWIE stars joined Amy Childs for the launch of her new CBD range

To save his daughter’s life, Emerson knew that he had to dig deep and find a treatment that would not only help Jorja but ultimately go on to help others.

At the time it was still illegal to prescribe cannabis in the UK. Emerson joined the campaign to see medical cannabis legalised in the UK in November 2018, and Jorja’s was among the first children to be legally prescribed medicinal cannabis.

In 2021 he went on to create the Jorja Foundation – a charity set up to help other families and children going through the same battles that Robin had to face.

The Jorja Foundation’s core principles are to fund special needs equipment that is not funded through the health system, fund family counselling, private appointments and tests when a second opinion is needed, as well s cannabis-based treatment for children in the UK and to continue to campaign and educate for wider NHS access in the UK for cannabis-based medications.  

Childs commented: “When I saw Robin & Jorja’s story on social media it broke my heart.

As a mum, I couldn’t imagine the pain of being told to take my child home to say goodbye to them. I love that Robin has fought for Jorja & is now helping other families with the Jorja Foundation. 

“I’m so happy that I can help the foundation by being the Creative Director of Jorja Botanicals. We have created some beautiful products for the whole family to enjoy. We will be donating a percentage of the proceeds to the foundation so that we can help as many families as possible. ”

 Emerson added: “ This is the fruition of a lot of hard work over many months and I am extremely proud to launch what is the first family brand in this category. In the coming weeks, we will also be launching a ‘parent’ focused cosmetic range in partnership with our creative director Amy Childs and our premium line of tincture oils.”

 

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South Africa launches first trial of cannabis for chronic pain

The study will test whether cannabis can replace opioids in the management of chronic pain.

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South Africa’s first cannabis trial has launched after initial results “show promise” for the treatment as a replacement for opioids.

The Pharma Ethics Observational Study is led by Biodata, a subsidiary of Labat Africa, and will test whether cannabis can replace opioids in the management of chronic pain.

The study will involve 1,000 participants who have been taking opioids for pain management for at least three months and are prepared to switch to cannabis as an alternative.

Biodata is the brainchild of Dr Shiksha Gallow, a cannabis clinician and the principal investigator in the trial which took over 18 months to get official clearance.

US research programme studies cannabinoids in ovarian cancer

Dr Gallow said the trial is set to be ground-breaking as South Africa’s first real-world study of medical cannabis. Researchers predict that it will provide much-needed insight into the link between cannabis genetics and patient outcomes.

Dr Gallow told Cannabiz Africa: “We are currently recruiting patients, and data-capturing all the questionnaires and feedback from the patients for the live Study. It has been fairly slow. However, more options have been introduced, as suggested by the patients in the pilot study.

“The pilot results of the study were very promising, as it showed 98 per cent of the patients have some sort of pain relief from the cannabis.

“We were able to wean these patients off their opioid treatment. In the pilot group of patients below the age of 55, it was shown this group preferred to smoke cannabis and patients older than 55 years preferred oil. The patients who smoked the cannabis had relief almost immediately, while the oil took some time to alleviate their pain.”

“Once we reach the sample size required and all of the relevant data has been collated, the results of the study will be published. We have currently renewed this study for another year, due to the initial slow uptake of research participants.”

Patients can apply to be research participants through the Biodata website.

Labat is expanding its footprint over the next few months with the introduction of CannAfrica kiosks in major shopping malls.

The company believes these will be the “ideal locations for physical sign-up points for the study”.

Labat said the kiosks will also serve as Biodata dispensaries and is engaging with a number of vape stores to do the same, although these would have to be subject to South African Health Products Regulatory Authority’s pharma-ethics requirements.

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