Connect with us

Science

Success for early trial exploring CBD treatment for epilepsy in dogs

A top professor at The Hebrew University of Jerusalem believes the CBD formulation holds “immense potential”.

Published

on

Innocan CBD in dogs study

An early study looking at the potential of CBD as a treatment for epilepsy in dogs has produced promising results.

A small-scale efficacy trial in dogs with refractory (drug-resistant) epilepsy has produced positive results, showing that dogs had a decrease in the frequency of their epileptic seizures after taking CBD.

Innocan Pharma Corporation announced the successful preliminary results this week. In the  initial phase of research, the dogs were treated with Innocan Pharma’s LPT (CBD Loaded Liposome Platform) injection, a unique CBD drug delivery platform. The trial is one of several ongoing studies that test the liposome platform on a range of potential conditions.

The experiments have demonstrated initial positive results, validating the viability of Innocan’s intention to make CBD available to humans and animals for extended periods upon a single dosage.

Innocan’s unique delivery method allows for the controlled release of CBD into the bloodstream with improved pharmacokinetic performance. By administering CBD encapsulated in liposomes, the scientists seek to achieve long-lasting and significant levels of CBD in the body, which the company believes will create a far more effective and continuous therapeutic effect.

The research was conducted in collaboration with the Hebrew University of Jerusalem and indicates the potential for the company’s technology to effectively deliver cannabinoids to the bloodstream.

Professor Chezy Barenholz of The Hebrew University said: “My lab is proud to be paving the way to what may be a veterinary world that infuses CBD on a regular basis. We take pride in our co-operation with Innocan Pharma that I believe holds immense potential.

“Innocan Pharma may be achieving sectoral leadership with our new results,” said Iris Bincovich, CEO of Innocan and added, “We are on the track to transitioning into later stages of drug development and these results will be crucial in determining the path ahead.”

The global animal healthcare market revenue was valued at US$141.2 billion in 2021 and is forecasted to reach US$181.7 billion by 2028. Studies suggest that the major factors driving the Animal Healthcare Market include the growing importance of animal health to pet owners.

Innocan is a pharmaceutical technology company that focuses on the development of several drug delivery platforms containing CBD. Ramot at Tel Aviv University is currently collaborating with the company on a new, “revolutionary” exosome-based technology that targets both central nervous system indications and the Covid-19 Corona Virus using CBD.

The product is expected to be administered by inhalation and be tested against a variety of lung infections.

Science

Researchers are using firefly genes to understand cannabis biology

Scientists know very little about how cannabinoid biosynthesis is controlled.

Published

on

firefly genes cannabis research

Scientists at the University of Connecticut are using the light-producing genes in fireflies to understand cannabis biology. The researchers hope the study will aid hemp farmers with the common problem of overproducing THC.

Cannabinoids are produced by trichomes, small spikey protrusions on the surface of cannabis flowers. Beyond this fact, scientists know very little about how cannabinoid biosynthesis is controlled.

Researchers at the University of Connecticut (UConn) are using funding from the US Department of Agriculture to discover the underlying molecular mechanisms behind trichrome development and cannabinoid synthesis. To do this, they will be looking at firefly genes.

The project is led by UConn research assistant professor Yi Ma and Gerry Berkowitz, professor in the College of Agriculture, Health and Natural Resources.

Berkowitz and Ma discovered factors responsible for trichome initiation and cannabinoid biosynthesis.  In this case, the factors cause epidermal cells on the flowers to morph into trichomes. The team’s discovery was recently published as a feature article in Plants. Related trichome research was also published in Plant Direct. Due to the gene’s potential economic impact, UConn has filed a provisional patent application on the technology.

With this new grant, the researchers will continue to explore how these factors play a role in trichome development during flower maturation. To do this, the researchers are making copies of firefly luciferase, the gene that allows fireflies to light up. The luciferase gene will be fused to the cannabis plant to generate light, indicating when there is an increase in trichome development.

“It’s a nifty way to evaluate signals that orchestrate cannabinoid synthesis and trichome development,” says Berkowitz.

Ma and Berkowitz will use an instrument called a luminometer, which measures how much light comes from the sample. This will tell the researchers if the regions they are looking at are controlled by the factors responsible for increasing trichome development.

Most cannabis farmers grow hemp, a variety of cannabis with naturally lower THC levels than cannabis. Currently, most hemp varieties that have high CBD levels also contain THC, sometimes at higher levels than is allowed.

This is likely because the hemp plants still make the enzyme that produces THC. In countries and regions where THC is illegal, hemp farmers must ensure the plant contains less than a certain percentage of THC. If it exceeds the limit, in many cases it must be destroyed. A better understanding of how the plant produces THC means scientists could selectively knock out the enzyme that synthesises THC using genome editing techniques. This would produce plants with lower levels of or no THC.

“We envision that the fundamental knowledge obtained can be translated into novel genetic tools and strategies to improve the cannabinoid profile, aid hemp farmers with the common problem of overproducing THC, and benefit human health,” the researchers say.

On the other hand, this knowledge could lead to the production of cannabis plants that produce more of a desired cannabinoid, which could prove helpful in altering the content of medical cannabis products.

In addition to sharing these findings with cannabis scientists, industry and growers, the researchers will incorporate this new knowledge into UConn courses on cannabis horticulture. The grant will also support the training of undergraduates interested in cannabis research, providing them with the skills to enter the workforce.

Continue Reading

Science

Jazz Pharmaceuticals announes top-line results from Phase 3 trial on MS

Nabiximols oromucosal spray continues to be evaluated in ongoing clinical trials in multiple sclerosis spasticity.

Published

on

jazz pharmaceuticals

The safety profile in a recent phase 3 trial on multiple sclerosis was consistent with previously reported adverse events, with no new safety signals attributable to nabiximols oromucosal spray.

Jazz Pharmaceuticals announced top-line results from its Phase 3 ‘RELEASE MSS1’ trial today (28 June), evaluating nabiximols oromucosal spray on clinical measures of spasticity in individuals with multiple sclerosis (MS).

Nabiximols oromucosal spray (branded as Sativex)  is a complex botanical mixture formulated from extracts of the cannabis sativa plant and contains the cannabinoids delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as other cannabinoid and non-cannabinoid components.

Nabiximols spray was first approved in the UK in 2010 and has been approved in 29 countries for the treatment of adult patients with moderate to severe spasticity due to MS who have not responded adequately to other anti-spasticity medication.

“We remain committed to the nabiximols program and are actively assessing the RELEASE MSS1 trial results, which will be presented at a future medical meeting. We look forward to additional data from two other ongoing trials that have the potential to support a US FDA New Drug Application submission,” said Rob Iannone, global head of research and development at Jazz Pharmaceuticals.

“I would like to extend a heartfelt thank you to all those who supported and made this study possible, including the patients who were enrolled, their families, our investigators, staff, and all of the dedicated Jazz employees.”

Veterans mental health CBD and cannabis: British army physical health

RELEASE MSS1 was the first, and smallest, of the three clinical trials in the current program. It evaluated the safety and efficacy of nabiximols spray in 68 patients with MS spasticity. Data from these trials will continue to be evaluated as it becomes available to support the overall registrational program in the US

Two additional, ongoing Phase 3 trials are underway which will inform a comprehensive development plan.

RELEASE MSS3 is a Phase 3 multicenter, double-blind, placebo-controlled trial evaluating the efficacy of nabiximols oromucosal spray for the improvement of muscle spasms associated with MS over a 12-week treatment period. The estimated enrollment is 446 participants.

Jazz Pharmaceuticals will also run a randomised double-blind trial called RELEASE MSS5. The Phase 3 multicenter, placebo-controlled crossover trial will evaluate the effect of multiple doses of nabiximols spray on a clinical measure of velocity-dependent muscle tone in the lower limbs (Lower Limb Muscle Tone-6). 190 participants are expected to be enrolled on the trial.

Full data from the RELEASE MSS1 trial will be submitted for presentation at a future medical meeting, the company said.

Continue Reading

Science

UK doctors present “leading” research on medical cannabis

Doctors from Sapphire Clinics will present 20 pieces of research to the International Cannabinoid Research Society.

Published

on

UK doctors present “leading” research on medical cannabis
The UK Medical Cannabis Registry has now enrolled over 5,000 patients.  

Doctors from Sapphire Medical Clinic will present major findings on medical cannabis at an international conference this weekend.

Since 2018 doctors in the UK have been prescribing medical cannabis for several conditions,  such as chronic pain, anxiety, and post-traumatic stress disorder. 

Whilst an increasing number of patients are now receiving therapy, a critical barrier to access is a lack of the right evidence to enable the NHS to fund medical cannabis. 

However, thanks to the efforts of doctors and  scientists the UK is now leading the way in medical cannabis research.  

On Saturday 25 June, doctors from Sapphire Medical Clinics will present 20 individual pieces of research at the annual International Cannabinoid Research Society (ICRS) Annual Conference in Galway, Ireland.

In this they will describe the outcomes and safety of medical  cannabis therapy in patients with a wide spectrum of disorders, including, but not limited to, chronic pain, anxiety, post-traumatic stress disorder, insomnia, and childhood epilepsy. 

Within this plethora of research, they will present data from the largest bespoke medical  cannabis registry in Europe, the UK Medical Cannabis Registry, which has now enrolled over 5,000 patients.  

This latest analysis reports the outcomes of nearly 2,833 patients with a range of conditions for which medical cannabis was prescribed since 2019. 

The conditions included chronic non-cancer pain, anxiety, fibromyalgia, and neuropathic pain. The average age of the patients  was 42 years and 43 per cent were women. The patients were assessed across a variety of  validated metrics to assess changes in health at one, three, six and 12 months. 

The researchers report: “This study, the largest observational series of patients prescribed  cannabis-based medicinal products in the UK, demonstrates an association with improved  general health-related quality of life up to 12 months. 

In addition, specific improvements in generalised anxiety and sleep quality were also observed. The majority of adverse events were mild and moderate.” 

They added: “Whilst randomised controlled trials are essential to determine causality, this study helps inform current clinical practice and future trials, whilst also being a  fundamental component of pharmacovigilance.”

Apart from pain, the researchers presented other studies looking at medical cannabis for the  treatment of palliative care, headache disorders, insomnia, depression, post-traumatic stress  disorder and inflammatory bowel disease. 

World-leading research

Commenting on the findings, Dr Simon Erridge, head of research and access at Sapphire Medical Clinics, said: “Medical cannabis is not a panacea, and not all patients respond to  therapy. 

“However, we do know from the latest review of the literature published in the British  Medical Journal of medical cannabis oils in chronic pain that they produce, on average, a 10 per cent improvement in pain scores in patients. That may not sound a lot – but for patients  where nothing else has helped, this reduction in pain is greatly valued.” 

He added: “The research we are presenting at ICRS is very complementary to existing studies and helps us to further understand the long-term effects of therapy. Most notably we have demonstrated both condition-specific and overall improvements to health-related  quality of life. These outcomes are reported by patients and directly reflect changes they experience in day-to-day life.”  

The research also showed that alongside patients who were new to cannabis, those who had previously been accessing it illicitly also reported improvements. 

Dr Erridge continued: “Another very interesting finding that we have demonstrated through sub-group analysis is that in addition to patients who were naïve to cannabis having an overall improvement as a group, a similar effect size was also seen in those previously accessing illicit cannabis. This suggests that the quality and consistency of medical cannabis prescribed by a trained  professional is an important facet of cannabis-based therapy.” 

He described the UK as a “leader” in medical cannabis research, but went onto highlight the need for national bodies to fund more randomised control trials alongside real-world evidence. 

He added: “We are pleased that through collecting, analysing, and publishing this data we are playing  our part in ensuring the UK is a leader in medical cannabis research. However, randomised  controlled trials are still necessary. 

“For the UK to remain on the front foot it is important that funding bodies, such as the National Institute for Health Research, recognise the promising  signals we present in our research and the potential impact these may have through  committing funding towards further randomised controlled trials.”  

“In the meantime, we will continue to publish the promising real-world effects seen in UK  patients.” 

 

Home » Science » Success for early trial exploring CBD treatment for epilepsy in dogs

Continue Reading

Trending