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How CBD could help tackle opioid addiction

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“Opioids are a huge driver of overdose deaths in the US." - Sohail R. Zaidi, President of ANANDA.

A new study will explore the effect of a unique CBD technology on reducing opioid consumption in chronic pain patients.

US biotech pharma company, ANANDA have announced a second clinical trial to evaluate the effect of cannabidiol in its unique delivery technology, on opioid sparing in participants with chronic pain syndromes.

An Investigational New Drug (IND) application has been approved by the US Food and Drug Administration (FDA) for the trial, which will be led by researchers at NYU Grossman School of Medicine, using ANANDA’s proprietary Liquid Structure™ CBD.

Pre-clinical and initial clinical studies show ANANDA’s Liquid Structure technology enhances the effectiveness and stability of CBD. 

This innovation creates new potential to facilitate voluntary opioid sparing and the ability to reduce opioid intake in patients being treated for chronic pain.

“Approval of a second clinical trial with this world-renowned institution further advances applications for CBD in ANANDA’s patented delivery technology in an area that could positively impact the lives of a large number of people suffering from opioid addiction,” said Sohail R. Zaidi, ANANDA’s President.

“Opioids are a huge driver of overdose deaths in the US and non-addictive therapy is a significant unmet need.”

The trial is being conducted at NYU Grossman School of Medicine led by principal investigator Stephen Ross, MD, Associate Professor Department of Psychiatry and Director NYU Addictive Disorders and Experimental Therapeutics Research Laboratory.

 Funding for this trial is from National Institute on Drug Abuse (NIDA), with additional support from ANANDA Scientific.

“Expanding research on therapeutic alternatives to opioid pharmacotherapies for chronic pain disorders, such as CBD medicinal products, is critical to reversing the opioid epidemic,” said Dr Ross.

“ANANDA’s commitment to safe, efficacious, high-quality products, paired with their groundbreaking delivery technology, creates tremendous opportunity for the development of evidence-based CBD medicinal products to reduce opioid intake and pain. 

“We look forward to collaborating with ANANDA on this important clinical work.”

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Case Studies

“I’ve been given so many labels, but CBD made me feel normal again”

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Matthew Cobb and his family

Founder of the cannabidiol brand, Euphoria CBD, talks to Cannabis Health about how CBD has helped him turn his life around and move on from the trauma of his childhood.

23-year-old Matthew Cobb says he has seen “way too much” for someone his age.

At the age of 12, Matthew was taken into the care system, suffering from serious mental health issues stemming from traumatic events in his early youth.

Throughout the course of his childhood, he was diagnosed with PTSD, autism spectrum disorder, multiple personality disorder and bipolar and was given medication in an effort to treat his mental health.

“I took medication from a very young age,” Matthew says over the phone.

“I suppose a lot of it at the time was my mum trying to find a reason as to why my behaviour was the way it was.”

His doctors prescribed him medications such as Ritalin, Concerta XL, sertraline and olanzapine to cope but none of them worked for him and the side effects were, at times, crippling.

“Prescribed medication was very prominent in my childhood. They didn’t really do anything for me but I was forced to take them every day,” he says.

“There was not one [medication] that I could take and feel myself. Some of them made me angry, some of them absolutely tore me apart and made me borderline suicidal.”

Eventually, the side effects became too much, and Matthew decided to stop taking prescription medication at 15-years-old.

Having first encountered cannabis at the age of 13, he began to solely rely on “medicating” through the drug. In his late teenage years, Matthew says he would often consume upwards of £70 worth of cannabis in one day.

“It was the only thing that gave me some sense of normality at the time. The fact that ‘stoned’ was the closest to normality that I could get at 17-years-old was a problem,” he says.

At the age of 18, Matthew stumbled across CBD for the first time in a local convenience store where he saw a pack of CBD flower for sale.

“I saw this thing that ultimately looked like cannabis. I’d never heard of CBD before,” he recalls.

He bought the 0.5 g pack and went to the local park to roll a ‘CBD joint’ and was astounded by the effects.

“It was just a feeling of constant relaxation. I didn’t feel paranoid. I didn’t feel like anyone was judging me,” he says.

Later, Matthew began to experience more profound benefits as his consumption of CBD began to positively impact his mental health.

“I started to notice that my depression was easing off and I was starting to feel better in myself,” he continues.

“It was completely different to smoking cannabis. I wasn’t getting high anymore, but I was sleeping again and I was eating properly. My head didn’t feel so up in the air, I didn’t feel manic.”

For Matthew, smoking cannabis was never about getting high. He just wanted to feel “normal”, and cannabis was the only substance he could find that got him close to that feeling.

“I had a lot of issues that I didn’t understand, a lot of issues that didn’t make sense,” he says.

“I was heading in a massive downward spiral and [cannabis] was the only thing that took the edge off.

“It was about making me feel some sense of normality. I got that with CBD, so it almost made cannabis null and void.”

With a renewed clarity of mind, Matthew realised that he had to make a change in his life.

“In two years, you’re going to be in prison or you’re going to be dead,” he thought.

Matthew says he hasn’t picked up a cannabis joint since the first time he tried CBD and from that moment, he was himself for the first time in his life. He no longer recognises in himself the mental health issues that he was diagnosed with as a child.

“My view is I don’t have any mental health issues,” he says.

“I was given many different labels, but they would change week to week; ADHD, bipolar disorder, personality disorder this, personality disorder that, depression.

“I had had a label for everything, but my life now is pretty normal.

“CBD has taken those labels away. It has given me something that no medication could; it’s given me – me.”

Having experienced first-hand the benefits of CBD, Matthew launched his own brand, Euphoria CBD, in July 2020.

It is set to launch a range of new products throughout 2021, including e-liquids, soap bars, bath bombs, moisturiser creams.

Frustrated with the lofty costs of CBD products, he set out to make high-quality cannabidiol affordable. Recalling a time in his life where he was struggling to make ends meet and pay for the supplement that had such a huge impact on his life, Matthew aims to make CBD accessible to everyone, regardless of their income.

“CBD is something that comes with benefits for so many different people, but the problem is that people don’t realise how much poverty there actually is in this country,” he adds.

“People can’t afford this kind of product, it’s just not possible. My goal is to provide an affordable product that genuinely helps people.”

 

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Mental health

Five tips for coping with life after lockdown

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Social distancing restrictions are set to end in England on June 21st

As much as many of us can’t wait for life to return to normal, after over year of living with some form of restrictions, it’s normal to be feeling a little bit anxious about life after lockdown.

From March 8 onwards, the UK will start to slowly emerge from lockdown, with schools opening first, followed by non-essential shops and leisure facilities over the coming months.

And while there are things about the return to ‘normal’ that we will all be looking forward to, it’s not unusual to be feeling a little apprehensive, or even anxious, about re-entering society. 

Luckily, there are a number of ways you can manage your anxiety – and the sooner you start, the more effective it will be.

Take it slowly

If you’re feeling worried, it’s probably best not to book tickets for a festival or a round-the-world cruise. Instead, aim to maybe meet up with one person at a time, or have a coffee at an outside café. Whatever you choose, it’s best to do something, as the longer you leave it, the worse your anxiety will be.  

Keep in touch

While Zoom and text fatigue have definitely set in after 12 months of lockdowns and distancing, now is the time to rekindle some of those connections.

Even if you don’t meet up in person just yet, it can be good to chat through your anxiety with a friend – chances are, they’ll know exactly how you’re feeling.

Try something new

Try to vary your routine so you see different people and situations until you find what you’re comfortable with. Maybe your usual walking route is very busy in the mornings; now the nights are getting lighter, try going out in the early evening. 

Trying something different can also break any negative connections you may associate with lockdown; if your local streets were as far as you travelled during lockdown, a walk around a different neighbourhood gives your brain a clear signal that something has changed.

Have a plan

While you can’t control everything, you do have power over some aspects of returning to a more normal life. If you’re feeling worried or anxious about going out, make yourself an action plan of how you’re going to handle it – and how you’ll respond to anything unexpected.

A little extra help

CBD is well known for its calming effects, and many people use it to relieve symptoms of anxiety.  Although more research is needed to understand the science behind using CBD as a treatment for anxiety, plenty of people anecdotally report a positive impact on their symptoms. A 2019 Gallup Poll discovered that 37 percent of CBD users take the supplement for anxiety.

CBD is thought to work by changing serotonin signals in the body through the interaction with CB1, a receptor found in the central nervous system.

Low serotonin levels are generally linked with depression, however there is also evidence that it could be a cause of anxiety.

In another study from 2019, researchers gave 300mg of CBD (or a placebo) to 37 Japanese teenagers suffering from social anxiety.

The results found that the group who received CBD experienced a significant reduction in their symptoms and concluded that “the results indicate that CBD could be a useful option to treat social anxiety.”

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Health

Integro Medical Clinics: How cannabis can help manage migraine pain

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Sponsored feature

The experts at Integro Medical Clinics explain how cannabis medicines can help manage and alleviate the excruciating pain of migraine.

Migraine can be a devastating and utterly miserable condition that can have a profound effect upon the patient’s quality of life.

But medical cannabis can offer a really effective, side-effect free treatment option, as we see in our patients’ story with Mike.

A migraine is categorised as a moderate or severe headache felt as a throbbing pain on one side of the head. It is generally accompanied with symptoms such as feeling sick, vomiting and increased sensitivity to light or sound.

It’s a common health condition, affecting around one in every five women and around one in every 15 men and they usually begin in early adulthood.

No one knows exactly what causes migraines, although they are thought to be the result of temporary changes in the chemicals, nerves and blood vessels in the brain.

Many patients find they have a specific trigger such as certain food or drink, stress, tiredness or hormonal changes such as starting your period. Around half of all people who experience migraines also have a close relative with the condition.

There are several types of migraine, including:

migraine with aura – where there are specific warning signs just before the migraine begins, such as seeing flashing lights

migraine without aura – the most common type, where the migraine happens without the specific warning signs

migraine aura without headache, also known as silent migraine – where an aura or other migraine symptoms are experienced, but a headache does not develop

The frequency of the occurrence of migraines really depends upon the individual. It can be several times a week to every few years.

There’s no one specific cure for migraines. Patients try pain medicines such as paracetamol and ibuprofen and triptans to help with the pain but these medicines are often ineffective.

If you suspect a specific trigger is causing your migraines, such as stress or a certain type of food, avoiding this trigger may help reduce your risk of experiencing migraines.

It may also help to maintain a generally healthy lifestyle, including regular exercise, sleep and meals, as well as ensuring you stay well hydrated and limiting your intake of caffeine and alcohol.

Cannabis medicines have been found by certain patients to be incredibly helpful in the management of pain.

Dr Anthony Ordman, senior clinical adviser and hon. clinical director of Integro Clinics explains why: “Recent medical scientific research is showing that cannabis medicines can have several useful roles in the prevention of migraine, and also reducing pain if a migraine attack does occur.

“It is likely that substances in cannabis medicines (plant-derived CBD, THC and terpenes) all have roles to play and that they supplement the activity of the brain’s naturally occurring endocannabinoid system. This system may be under-active in people prone to migraine.

“There are three likely mechanisms by which cannabis medicines may be effective. Firstly, the natural stabilising or anticonvulsant effect of the cannabinoids suppresses the spreading abnormal wave of voltage depression in the brain’s cortical neurones. This wave precedes all migraine attacks and causes the aura familiar to migraine sufferers.

“Secondly, cannabis substances are thought to stabilise the mast cells of the immune system. In migraine, mast cells are involved in dilatation, or opening up of the blood vessels of the brain’s lining (dura), causing that familiar pulsating headache. Cannabis medicines may prevent this process from occurring.

He adds: “And finally, as in other painful conditions, if a migraine does occur, cannabis medicines are likely to block the transmission of pain messages in nerves running from the brain stem to the pain centres of the brain, to reduce pain itself.

A recent study showed that cannabinoids may reduce migraine severity by 49.6 percent without causing the ‘overuse headache,’ that other pain medicines such as paracetamol may cause.”

The patient’s story

Mike is a physically fit 37-year-old South African, who first experienced migraines as a teenager.

The pain he suffered was agonising and totally debilitating. It disturbed his vision, caused nausea and deep pain. Prior to the onset he experienced the aura of lights and would go blind in one eye.

An attack could wipe out days of his life whilst he recovered. For several days after the attack, he would feel befuddled and that his brain was not working properly.

Initially he looked into what could be causing the migraines worrying that he might have a brain tumour, but MRI scans thankfully showed that this was not the case. It was through luck and circumstance he stumbled upon cannabis as a medicine for his condition.

Mike was out playing golf in the hot sun and he became dehydrated. He felt the first symptoms of the headache begin so he paused for a rest under a tree and smoked some cannabis.

Instantly, he felt the pain begin to recede and he knew he had found a solution to his condition. He also wanted to point out that he was able to finish his round of golf and win. He came to the realisation that dehydration and hot sun were his major triggers.

Using cannabis would also mean that when a migraine did come it would last for a much shorter period of time and there was none of the post attack brain fog.

“I cannot recommend medical cannabis highly enough as treatment for migraine,” says Mike.

“It addresses all of the symptoms of the loss of vision, nausea and deep pain by addressing the inflammation in the blood vessels of the brain.”

Dr Ordman adds: “Integro Medical Clinics always recommend remaining under the care and treatment of your GP and specialist for your condition, while using cannabis-based medicines, and the Integro clinical team would always prefer to work in collaboration with them.”

If you would like further information, or to make an appointment for a medical consultation, please contact us at Integro Clinics:

Website: www.integroclinics.com
Email: Contact@integroclinics.com
Twitter: @clinicsintegro

Further help and support can be found at the following patient charities:

https://www.migrainetrust.org/ @MigraineTrust

https://www.nationalmigrainecentre.org.uk/ @NatMigraineCtr

https://headachemigraine.org/connect-with-others/ @CoalitionCHAMP

https://painuk.org/members/charities/migraine-trust/ @Pain_UK

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