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First large-scale clinical trials launched on rare cannabinoids

Studies will examine the effects of THCV, CBN, CBG, and CBC on energy, focus, appetite, sleep disturbance, pain, stress, and anxiety.



Pebble Life Sciences, a Texas-based cannabinoid company has partnered with a leading US cancer research centre
The trials will examine the effects of THCV, CBN, CBG, and CBC

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Several new clinical trials will explore the health and wellness potential of rare cannabinoids including THCV, CBN, CBG, and CBC.

US health tech company, Radicle Science, has launched the first large-scale, blinded placebo-controlled clinical trials on rare cannabinoids, which are expected to get underway in 2022.

The trials will examine the effects of THCV, CBN, CBG, and CBC on energy, focus, appetite, sleep disturbance, pain, stress, and anxiety in 10,000 participants.

In 2021, Radicle Science conducted what is claimed to be the world’s largest randomised control trial (RCT) on CBD products and their effect on key health outcomes across five domains including general well-being, quality of life, sleep quality, pain, and feelings of stress and anxiety.

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Radicle ACES (Advancing CBD Education and Science) is also history’s largest longitudinal RWE study to determine the effectiveness of botanical products containing CBD, including nearly 3,000 participants.

Initial findings indicated participants experienced a 71 per cent improvement in their well-being, on average, across all the products.

Many brands also underwent a Radicle Real World Sleep study (RRWS), an RCT which researched the effectiveness of orally ingestible CBD products for sleep. 

Researchers found that among participants with pre-existing sleep complaints, on average 65 per cent experienced a clinically meaningful improvement in their sleep quality after taking one of the CBD brands. 

In total over 2,000 participants from diverse geographical areas in the US participated across all of these RRWS studies, including 10 per cent from hard-to-reach rural and semi-rural populations typically not represented in clinical studies. 

Co-founder and CEO of Radicle Science, Dr. Jeff Chen, MD/MBA, said: “We are headed for exponential growth in 2022 as we prepare to study 10 times more people than we did in 2021.

“We aim to support our mission of creating a movement that redefines the research paradigm and enables evidence-based decision making across the health and wellness industry, starting with cannabinoids.”

The company is set to begin studying the effects of the less common cannabinoids in the first half of 2022.

Brands taking part in the upcoming trials include Columbia Care, Lord Jones, Open Book Extracts, Straight Hemp, Trokie®, and Wana Brands.

People from diverse backgrounds, demographics, and ages are encouraged to sign up to participate in the studies, the findings of which will be shared with consumers, regulators, manufacturers, and healthcare providers to help shape the future of cannabinoid clinical research.

Pelin Thorogood, co-founder and executive chair of Radicle Science, commented: “Our virtual, direct-to-consumer, crowdsourced approach enables Radicle Science to democratise access to rigorous studies, allowing us to serve diverse brands, from startups to multibillion dollar publicly traded companies.

“We are also proud to provide verified products and personalised health reports free of charge to thousands of individuals across the country who participate in our studies.”

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Sarah Sinclair is a respected cannabis journalist writing on subjects related to science, medicine, research, health and wellness. She is managing editor of Cannabis Health, the UK’s leading title covering medical cannabis and CBD, and sister title and Psychedelic Health. Sarah has an NCTJ journalism qualification and an MA in Journalism from the University of Sunderland. Sarah has over six years experience working on newspapers, magazines and digital-first titles, the last two of which have been in the cannabis sector. She has also completed training through the Medical Cannabis Clinicians Society securing a certificate in Medical Cannabis Explained. She is a member of PLEA’s (Patient-Led Engagement for Access) advisory board, has hosted several webinars on cannabis and women's health and has moderated at industry events such as Cannabis Europa. Sarah Sinclair is the editor of Cannabis Health. Got a story? Email / Follow us on Twitter: @CannabisHNews / Instagram: @cannabishealthmag


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